"Urushinge rumwe, umwaka umwe wo gusinzira; kuvura ingirabuzimafatizo bitanga isezerano ryo gukiza abarwayi badasinzira miliyoni 300."

Gusinzira ntibikiriho gusa abasaza. Urubyiruko rwinshi kandi rufite ibibazo byo gusinzira nabi.

Aya makuru yerekana ko mu Bushinwa hari abantu bagera kuri miliyoni 300 bafite ibibazo byo gusinzira cyangwa kubura ibitotsi, aho umuntu umwe ku icumi ugereranyije afite ikibazo cyo gusinzira. Iki kibazo nticyagarukira gusa ku bageze mu za bukuru; abantu bakuru ndetse n'abana bahura nuburyo butandukanye bwo guhungabanya ibitotsi. "Kubura ibitotsi" mubushinwa bisa nkaho byabaye ikibazo mumyaka yose.

Mugihe ibitera kudasinzira bitandukanye, ibibazo bitandukanye bizana bigira ingaruka kubuzima bwabantu. Umuti wo kudasinzira udafite uburambe bunoze, kandi nubwo ibinini byo kuryama bishobora gutanga ubutabazi bwigihe gito, gukoresha igihe kirekire bishobora gutera ingaruka nyinshi. Ku rundi ruhande, imiti itari imiti, iragoye kandi itwara igihe, hamwe n’imikorere idahwitse, bigatuma abarwayi kuyikurikiza bigorana.

Kubwibyo, gushakisha uburyo bushya bwo kuvura byahindutse intumbero yimbaraga zabaganga, kandi ibisubizo bitanga umusaruro wumugozi mesenchymal stem selile therapy nta gushidikanya byafunguye inzira nshya yo kuvura ibitotsi.

Ingingo yo muri "Ikinyamakuru cyo mu Bushinwa cya Clinical Psychology" yerekanye ibyavuye mu mavuriro yo mu nda ya mesenchymal stem selile yo kuvura kudasinzira. Ibisubizo byerekanye ko mu itsinda rishinzwe kuvura ibiyobyabwenge, 80% bahuye n’ibimenyetso byo kudasinzira no kongera kwiyongera, mu gihe mu itsinda ryita ku ngirabuzimafatizo, abarwayi bavuwe rimwe gusa bagaragaje ko hari byinshi byahinduye cyane mu gusinzira ndetse n’ubuzima bwiza, bushobora kumara umwe. umwaka nta reaction igaragara ihari.

Ahari, ingirabuzimafatizo zizana ibyiringiro bishya kubaturage benshi barwaye kudasinzira.

01

Kudasinzira = Kwiyahura karande?

Kuki muri iki gihe urubyiruko narwo rwinjira mu mutwe w "ingabo" zidasinzira?

Ubushakashatsi bwerekana ko umuvuduko ukabije w'akazi ariwo nyirabayazana w'ingenzi ugira ingaruka nziza ku gusinzira, hagakurikiraho guhangayikishwa n'ubuzima, ibintu bidukikije, ingeso z'umuntu, n'ibindi. Abantu barenga 58% bafite ubushake bwo guta igihe cyo gusinzira kugirango barangize imirimo yabo ikomeye.

Ariko, mugihe utamba ibitotsi, ningaruka zubuzima nazo ziraterwa. Usibye gutera umunaniro no kurakara, kudasinzira bishobora no kongera ibyago byo kurwara.

Gusinzira bisanzwe ni igihe sisitemu nyinshi z'umubiri zimeze muri synthesis na metabolism. Ibi bifasha mukugarura sisitemu yumubiri, nervous, skeletale, n imitsi, bityo bigakomeza imirimo itandukanye yumubiri. Ku bantu bakuru, amasaha 7-8 yo kuryama kumunsi arakenewe. Kudasinzira neza cyangwa gusinzira bidahagije birashobora kongera ibyago byindwara zitandukanye, nk'umubyibuho ukabije, diyabete, kanseri, n'indwara z'umutima.

Byongeye kandi, kubura ibitotsi igihe kirekire birashobora guhungabanya umubiri wawe! Ubushakashatsi bwakorewe mu Budage bwerekanye ibi, bwerekana ko kubura ibitotsi bigabanya cyane imikorere ya selile T, zikenerwa mu kongera ubudahangarwa bw'umubiri no kurwanya kanseri.

Gα ifatanije na reseptor yerekana no kugenzura ibitotsi ihindura imikorere ya antigen yihariye ya selile yumuntu.

Birashobora kugaragara ko kudasinzira bihwanye n "" kwiyahura karande "kumuntu usanzwe. Nyamara, mubikorwa byubuvuzi, usibye uburyo bwo kuvura imiti nubudafite imiti, nta bundi buryo bwo kuvura ibitotsi bidakira. Byongeye kandi, ingaruka mbi zibiyobyabwenge zirahambaye, kandi imiti itari farumasi itwara igihe kandi ikunda gusubira inyuma, yamye yibasira benshi mubarwayi badasinzira.

02

Miliyoni 200 zo kudasinzira, zirinzwe ningirangingo.

Kugaragara kwingirangingo fatizo byazanye ibyiringiro kubibazo byinshi byubwonko.

Kudasinzira igihe kirekire akenshi biherekejwe nimirire mibi ya neuronal, atrophy, degeneration, ndetse na apoptose, bigahungabanya homeostasis yumubiri wumubiri. Irashobora kandi guteza imbere irekurwa rya cytokine ikongora, biganisha ku bihe nko kwiheba, guhangayika, no kurwara imitsi.

Umbilical cord mesenchymal stem selile ifite ingirabuzimafatizo nziza zo gusana, guhinduranya umubiri, hamwe no kurwanya inflammatory. Iyo bikoreshejwe ku barwayi bafite ikibazo cyo gusinzira, birashoboka ko bigira ingaruka nkizo mu gusana ingirangingo no kugabanya umuriro, bityo bigatuma ibitotsi bisinzira.

Nyuma yo kwimura ingirangingo ngengabuzima mesenchymal stem selile mu barwayi 39 bafite ikibazo cyo kudasinzira karande kandi nyuma y’amezi 12, ibisubizo byagaragaje ko itsinda ryavuwe no guhinduranya ingirabuzimafatizo ryerekanye ko ryazamutse cyane mu mibare y’ubuzima ndetse n’amanota meza yo gusinzira ukwezi kumwe nyuma yo kuvura ingirabuzimafatizo ugereranije na mbere yo kuvurwa. Iterambere ryakomeje mugihe cyakurikiyeho ugereranije na mbere yo kuvurwa.

Nubwo itsinda rishinzwe kuvura ibiyobyabwenge ryabanje kwerekana umusaruro ushimishije, nyuma y’amezi 3 yo kuvurwa, ubuzima bw’abarwayi n’amanota meza yo gusinzira byatangiye kugabanuka, byerekana itandukaniro rito ugereranije na mbere yo kuvurwa.

Kugereranya amanota yabarwayi mbere na nyuma yo kuvurwa mumatsinda yombi.

Icy'ingenzi cyane, 80% by’abarwayi bo mu itsinda ryita ku miti bahuye n’ibimenyetso byo kudasinzira cyane, bitagaragaye mu itsinda rivura ingirabuzimafatizo. Ubuvuzi bwa stem selile bwateye imbere kandi bunoze bwo kuvura ibitotsi hamwe nigihe kimwe gusa kandi birashobora kumara amezi agera kuri 12, nta ngaruka mbi zigaragara.

Ubushakashatsi bwemeje imikorere itanga ingirabuzimafatizo mu kuvura kudasinzira karande. Hamwe niterambere ryiterambere ryubuvuzi bushya, byizerwa ko ingirabuzimafatizo zishobora kwaguka mubice byinshi byindwara, bikazana ibyiringiro kubarwayi benshi.