"Inaliti enye, unyaka omnye wokulala; unyango lwe-stem cell lunesithembiso sokusindisa i-300 yezigidi zezigulane ezingapheliyo."

Ukuphuthelwa akusekho kwabakhulileyo kuphela. Bayanda abantu abaselula abakhathazwa kukungalali ngokwaneleyo.

Idatha ibonisa ukuba kukho malunga ne-300 yezigidi zabantu e-China abanengxaki yokulala okanye ukuphazamiseka kokulala, kwaye umntu omnye kwabalishumi ngokomndilili ufumana ukuphazamiseka kokulala. Lo mbandela awupheleli nje kubantu abadala; abantu abadala kunye nabantwana bafumana amazinga ahlukeneyo okuphazamiseka kokulala. "Ukunqongophala kokulala" kumxholo waseTshayina kubonakala ngathi kuyingxaki kuwo onke amaqela eminyaka.

Ngoxa oonobangela bokuphuthelwa bengafani, iingxaki ezahlukahlukeneyo eziziswa kuko ziyayichaphazela impilo yabantu. Unyango lokuphuthelwa alunawo amava asebenzayo, kwaye nangona iipilisi zokulala zinokunika isiqabu sexesha elifutshane, ukusetyenziswa kwexesha elide kunokukhokelela kwimiphumo emibi emininzi. Unyango olungelulo olwamayeza, kwelinye icala, lunzima kwaye ludla ixesha, lusebenza ngokungazinzanga, lusenza kube nzima ukuba izigulane zibambelele kuzo.

Ke ngoko, ukuphonononga amayeza amatsha kuye kwaba yingqwalasela yeenzame zoogqirha, kwaye iziphumo ezithembisayo zonyango lwe-umbilical cord mesenchymal stem cell ngokungathandabuzekiyo zivula indlela entsha yonyango yokuphuthelwa.

Inqaku elikwi "Jenali yaseTshayina yeClinical Psychology" yazisa iziphumo zonyango lwe-umbilical cord mesenchymal stem cell unyango lokuphuthelwa. Iziphumo zibonise ukuba kwiqela lonyango lwamachiza, i-80% yafumana iimpawu zokuphuthelwa kunye nokuphindaphinda, ngelixa kwiqela lonyango lwe-stem cell, izigulane ezifumene unyango kanye kuphela zibonise ukuphucuka okubonakalayo kumgangatho wobuthongo kunye nomgangatho wobomi, obunokuhlala ukuya kwelinye. unyaka kungekho ziziphumo zibi.

Mhlawumbi, iiseli ze-stem ziya kuzisa ithemba elitsha kubantu abaninzi abanengxaki yokuphuthelwa.

01

Ukungalali = Ukuzibulala Okungapheliyo?

Kutheni abantu abancinci namhlanje bezibandakanya noluhlu lwe "ibutho" le-insomniac?

Uphando lubonisa ukuba uxinzelelo oluphezulu lomsebenzi luwona nobangela ophambili ochaphazela umgangatho wokulala, olandelwa kukuxinezeleka kobomi, iimeko zokusingqongileyo, imikhwa yomntu, njalo njalo. Ngaphezulu kwe-58% yabantu bazimisele ukuncama ixesha lokulala ukuze bagqibezele eyona misebenzi ibalulekileyo.

Nangona kunjalo, ngelixa uncama ukulala, iingozi zempilo nazo ziyatyalwa. Ngaphandle kokubangela ukudinwa nokucaphuka, ukuphuthelwa kusenokwandisa ingozi yokugula.

Ukulala okuqhelekileyo kuxa uninzi lweenkqubo zomzimba zikwimo yokudityaniswa kunye nemetabolism. Oku kunceda ekubuyiseleni amajoni omzimba, i-nervous, skeletal, kunye ne-muscular systems, ngaloo ndlela igcina imisebenzi eyahlukeneyo yomzimba. Kubantu abadala, iiyure ezi-7-8 zokulala ngosuku ziyimfuneko. Ukungalali ngokwaneleyo okanye ukungalali ngokwaneleyo kunokwandisa amathuba okuba nezifo ezahlukahlukeneyo, njengokutyeba ngokugqithiseleyo, isifo seswekile, umhlaza, nezifo zentliziyo.

Ngaphaya koko, ukungalali ixesha elide kunokuwubeka esichengeni amajoni akho omzimba! Uphononongo olwenziwa eJamani lubonise oku, lubonisa ukuba ukulahlekelwa bubuthongo kunciphisa kakhulu ukusebenza kakuhle kweeseli ze-T, eziyimfuneko ekwandiseni ukuphendula komzimba kunye nokulwa nomhlaza.

I-Gα-coupled receptor signaling kunye nokulawulwa kokulala kulungelelanisa i-antigen-specific activation yeeseli ze-T zomntu.

Kuyabonakala ukuba ukuphuthelwa kufana "nokuzibulala okungapheliyo" kumntu oqhelekileyo. Nangona kunjalo, ekusebenzeni kweklinikhi, ngaphandle kweendlela zonyango ze-pharmacological and non-pharmacological, ayikho enye indlela yokunyanga ukulala okungapheliyo. Ngaphezu koko, iziphumo ebezingalindelekanga zamachiza zibalulekile, kwaye unyango olungelulo olwamayeza ludla ixesha kwaye luthambekele ekubuyeleni kwakhona, olusoloko luthwaxa uninzi lwezigulana zokungalali.

02

Izigidi ezingama-200 zabantu abaphuthelwa, ezikhuselwe ziiseli ze-stem.

Ukuvela kweeseli ze-stem kuzise ithemba kwiingxaki ezininzi ze-neurological.

Ukungalali ixesha elide kudla ngokukhatshwa kukungondleki kweneuronal, atrophy, degeneration, kunye ne-apoptosis, ephazamisa i-homeostasis yenkqubo yomzimba yokuzikhusela. Inokukhuthaza ukukhutshwa kwee-cytokines ezivuthayo, ezikhokelela kwiimeko ezinjengokudakumba, ukuphazamiseka kwexhala, kunye nokuphazamiseka kwengqondo.

Iiseli ze-umbilical ze-mesenchymal stem zinezinto ezintle zokulungisa izicubu, ukumodareyitha komzimba, kunye neempawu ezichasayo. Ukuba isetyenziswe kwizigulane ezinokuphazamiseka kokulala, zinokuthi zibe nemiphumo efanayo ekulungiseni izicubu kunye nokunciphisa ukuvuvukala, ngaloo ndlela kuphuculwe ukuphazamiseka kokulala.

Emva kokutshintshwa kweeseli ze-umbilical cord mesenchymal stem kwizigulane ezingama-39 ezinokulala okungapheliyo kunye nokulandela iinyanga ze-12, iziphumo zibonise ukuba iqela eliphathwe nge-stem cell transplantation libonise umgangatho ophuculweyo kakhulu wamanqaku obomi kunye namanqaku omgangatho wokulala kwinyanga enye emva konyango lwe-stem cell xa kuthelekiswa nonyango. phambi kokuba unyango. Olu phuculo lwagcinwa ngexesha lokulandelelana lokulandela xa kuthelekiswa nangaphambi kokuba unyango.

Nangona iqela lonyango lwamachiza ekuqaleni libonise ukusebenza okuthembisayo, emva kweenyanga ze-3 zonyango, umgangatho wobomi bezigulane kunye namanqaku omgangatho wokulala aqala ukuhla, ebonisa umahluko omncinci xa kuthelekiswa nangaphambi konyango.

Ukuthelekiswa kwamanqaku esigulane ngaphambi nangemva kokunyanga kumaqela omabini.

Okona kubaluleke kakhulu, i-80% yezigulane kwiqela lonyango lwamayeza ziye zafumana iimpawu zokulala, ezingazange zibonwe kwiqela lonyango lwe-stem cell. Unyango lwe-Stem cell luphuculwe kwaye lwaphuculwa unyango lokulala ngeseshoni enye kwaye lunokuhlala ukuya kuthi ga kwiinyanga ezili-12, ngaphandle kokuphendula okubonakalayo.

Uphando luye lwaqinisekisa ukusebenza okuthembisayo kweeseli ze-stem ekunyangeni ukuphuthelwa okungapheliyo. Ngophuhliso oluqhubekayo lweyeza lokuvuselela, kukholelwa ukuba iiseli ze-stem zinokwandisa kwiindawo ezininzi zezifo, ezizisa ithemba kwizigulane ezininzi.