"Umjovo owodwa, unyaka owodwa wokulala; i-stem cell therapy inesithembiso sokusindisa iziguli ezingapheli eziyizigidi ezingu-300."

Ukuqwasha akusatholakali kwasebekhulile kuphela. Iyanda intsha ehlushwa ukungalali kahle.

Imininingwane ibonisa ukuthi cishe kunabantu abayizigidi ezingu-300 e-China abanenkinga yokulala noma ukuphazamiseka kokulala, futhi oyedwa kwabayishumi ngokwesilinganiso unenkinga yokulala. Lolu daba alugcini nje kwasebekhulile; abantu abadala ngisho nezingane baba namazinga ahlukene okuphazamiseka kokulala. "Ukuntuleka kokulala" kumongo wesiShayina kubonakala sengathi sekuyinkinga kuwo wonke amaqembu eminyaka.

Nakuba izimbangela zokuqwasha zihluka, izinkinga ezihlukahlukene okuzilethayo ziyayithinta impilo yabantu engokomzimba. Ukwelashwa kokuqwasha akunakho okuhlangenwe nakho okusebenzayo, futhi nakuba amaphilisi okulala anganikeza ukukhululeka kwesikhashana, ukusetshenziswa kwesikhathi eside kungaholela emiphumeleni eminingi engemihle. Ngakolunye uhlangothi, izindlela zokwelapha ezingezona ezemithi zinzima futhi zidla isikhathi, zisebenza ngendlela engazinzile, okwenza kube nzima ezigulini ukunamathela kuzo.

Ngakho-ke, ukuhlola izindlela zokwelapha ezintsha sekuyimizamo yodokotela abagxile kuyo, futhi imiphumela ethembisayo yokwelashwa kwe-umbilical cord mesenchymal stem cell ngokungangabazeki ivula indlela entsha yokwelapha yokuqwasha.

Isihloko ku-"Chinese Journal of Clinical Psychology" yethula imiphumela yomtholampilo ye-umbilical cord mesenchymal stem cell therapy yokuqwasha. Imiphumela yabonisa ukuthi eqenjini lokwelashwa kwezidakamizwa, ama-80% abhekana nezimpawu zokuqwasha futhi abuyela emuva, kuyilapho eqenjini lokwelashwa kwe-stem cell, iziguli ezathola ukwelashwa kanye kuphela zabonisa ukuthuthukiswa okuphawulekayo kwekhwalithi yokulala kanye nekhwalithi yokuphila, okungahlala kuze kube yinye. unyaka ngaphandle kokusabela okubi okuphawulekayo.

Mhlawumbe, ama-stem cells azoletha ithemba elisha kubantu abaningi abahlushwa ukuqwasha.

01

Ukuqwasha = Ukuzibulala Okungapheli?

Kungani abantu abasha kulezi zinsuku nabo bejoyina "ibutho" le-insomniac?

Ucwaningo lubonisa ukuthi ukucindezela okukhulu komsebenzi kuyimbangela eyinhloko ethinta izinga lokulala, kulandelwa ukucindezeleka kokuphila, izici zemvelo, imikhuba yomuntu siqu, njalonjalo. Abantu abangaphezu kuka-58% bazimisele ukudela isikhathi sokulala ukuze baqedele imisebenzi yabo ebaluleke kakhulu.

Kodwa-ke, ngenkathi kudela ukulala, izingozi zempilo nazo ziyatshalwa. Ngaphezu kokubangela ukukhathala nokucasuka, ukuqwasha kungase kwandise ingozi yokugula.

Ukulala okuvamile yilapho amasistimu amaningi omzimba esesimweni sokuhlangana kanye ne-metabolism. Lokhu kusiza ekubuyiseleni amasosha omzimba, izinzwa, amathambo namasistimu emisipha, ngaleyo ndlela kugcinwe imisebenzi ehlukahlukene yomzimba. Kubantu abadala, amahora angama-7-8 wokulala ngosuku ayadingeka. Ukungalali kahle noma ukungalali ngokwanele kungandisa ingozi yezifo ezihlukahlukene, njengokukhuluphala ngokweqile, isifo sikashukela, umdlavuza nesifo senhliziyo nemithambo yegazi.

Ngaphezu kwalokho, ukungalali isikhathi eside kungalimaza amasosha akho omzimba! Ucwaningo olwenziwa eJalimane luye lwabonisa lokhu, lubonisa ukuthi ukulahlekelwa ubuthongo kunciphisa kakhulu ukusebenza kahle kwama-T cell, abalulekile ekuthuthukiseni ukusabela komzimba kwamasosha omzimba nasekulweni nomdlavuza.

Isignali ye-Gα-coupled receptor kanye nokulawulwa kokulala kulungisa ukusebenza okuqondile kwe-antigen kwamaseli T womuntu.

Kuyabonakala ukuthi ukuqwasha kufana “nokuzibulala okungapheli” kumuntu ojwayelekile. Kodwa-ke, ekusebenzeni komtholampilo, ngaphandle kwezindlela zokwelapha ze-pharmacological and non-pharmacological, ayikho enye indlela yokwelapha ukuqwasha okungapheli. Ngaphezu kwalokho, imiphumela emibi yezidakamizwa ibalulekile, futhi ukwelapha okungezona ezemithi kudla isikhathi futhi kuthambekele ekubuyeni, okuhlale kuhlupha iningi leziguli zokuqwasha.

02

200 million insomniacs, evikelwe ama-stem cells.

Ukuvela kwama-stem cell kulethe ithemba ezinkingeni eziningi zemizwa.

Ukuqwasha isikhathi eside kuvame ukuhambisana nokungondleki kahle kwe-neuronal, atrophy, degeneration, ngisho ne-apoptosis, okuphazamisa i-homeostasis yamasosha omzimba. Ingase futhi ikhuthaze ukukhululwa kwama-cytokines avuvukalayo, okuholela ezimweni ezinjengokucindezeleka, ukuphazamiseka kokukhathazeka, nokuphazamiseka kwemizwa.

Amaseli we-stem mesenchymal we-umbilical cord anezinto ezinhle kakhulu zokulungisa izicubu, ukuguquguquka komzimba, kanye nezakhiwo zokulwa nokuvuvukala. Uma isetshenziswa ezigulini ezinokuphazamiseka kokulala, kungenzeka zibe nemiphumela efanayo ekulungiseni izicubu nokunciphisa ukuvuvukala, ngaleyo ndlela kuthuthukiswe ukuphazamiseka kokulala.

Ngemuva kokufakelwa kabusha kwe-umbilical cord mesenchymal stem cells ezigulini ezingu-39 ezinenkinga yokuqwasha okungapheli futhi kulandela izinyanga ezingu-12, imiphumela yembula ukuthi iqembu eliphathwe nge-stem cell transplantation libonise izinga lokuphila elithuthuke kakhulu kanye nekhwalithi yekhwalithi yokulala inyanga eyodwa ngemva kokwelashwa kwe-stem cell uma kuqhathaniswa ngaphambi kokwelashwa. Lokhu kuthuthukiswa kwagcinwa phakathi nenkathi yokulandelela elandelayo uma kuqhathaniswa nangaphambi kokwelashwa.

Nakuba iqembu lokwelapha izidakamizwa ekuqaleni libonise ukusebenza okuthembisayo, ngemva kwezinyanga ezingu-3 zokwelashwa, izinga lempilo leziguli kanye nekhwalithi yokulala yaqala ukwehla, ikhombisa umehluko omncane uma kuqhathaniswa nangaphambi kokwelashwa.

Ukuqhathaniswa kwamaphuzu esiguli ngaphambi nangemva kokwelashwa kuwo womabili amaqembu.

Okubaluleke kakhulu, ama-80% eziguli eziseqenjini lokwelashwa kwemithi zaba nezimpawu zokuqwasha kabusha, ezingazange zibonwe eqenjini lokwelashwa kwe-stem cell. Ukwelashwa kwe-stem cell kuthuthukisiwe futhi kwathuthukiswa ukwelashwa kokulala ngeseshini eyodwa nje futhi kungahlala izinyanga ezifika kweziyi-12, ngaphandle kokusabela okusobala okungekuhle.

Ucwaningo luye lwaqinisekisa ukusebenza okuthembisayo kwama-stem cells ekwelapheni ukuqwasha okungapheli. Ngokuthuthuka okuqhubekayo kwemithi yokuvuselela, kukholakala ukuthi ama-stem cells angakhula abe nezindawo eziningi zezifo, okuletha ithemba ezigulini eziningi.